Category Archives: Carcinoma of the breast

Chromosomal changes traveling withETV6-NTRK in secretory carcinoma of the breast

Gregor Krings led a multi-center group from the University of California, San Francisco, to compare histology and genetics of nine secretory carcinomas of the breast with six MASC salivary gland tumors. This post looks at breast secretory carcinoma chromosome changes that travel with the ETV6-NTRK3 gene fusion. While the TEL-TRKC fusion protein may be many vocal passengers, it seems to be only one actionable target.

Diagram showing genomic alterations in various patients with their sex and age.

A gain in the long arm or the entire chromosome 8 is seen in cases 1 and 3. A loss of the interstitial part of 15q or the entire chromosome is seen in cases 2 and 3

Secretory Carcinoma of the Breast IHC

Some detailed secretory carcinoma of the breast images to be compared with MASC

Dali Li and coworkers (2012) of the Fudan University Shanghai Cancer Center reviewed 15 FFPE preserved secretory breast carcinomas (SBC) that were collected between 2006 and 2010. One of their goals was to use histology and immunohistochemical (IHC) markers to determine if SBC in a Chinese population had a basal cell phenotype. The basal cell phenotype was defined as

  • HER2/ER negative
  • CK5/6 and EGFR positive

A goal on this post is to compare SBC with mammalian analog of secretory carcinoma (MASC) in salivary glands.  Both are now considered secretory carcinomas.

Secretory Carcinoma of the Breast, a review

Secretory Carcinoma of the breast, a review after nine years

In 2011 Pooja Vasudev and Kazuya Onuma of McMaster University published a nice review of secretory breast cancer. The following post follows the review and adds some additional images from a case study of Arce and coworkers  (2005)  to make it easier to understand. Unlike the six year old female in which secretory carcinoma of the breast was discovered, this cancer was found in a 52 year old male. 

Molecular comparison of breast and salivary gland secretory carcinomas

Comparing Secretory Carcinoma of the breast with MASC

Gregor Krings led a multi-center group from the University of California, San Francisco, to compare histology and genetics of nine secretory carcinomas of the breast with six MASC salivary gland tumors. For this post secretory carcinoma of the salivary glands will be referred to as MASC, mammary analog of secretory carcinoma of the breast.   Secretory carcinoma of the breast will simply be referred to as SC.

The genetic profile of the tumors in one  image

Diagram showing genomic alterations in various patients with their sex and age.

Figure 1, adapted from Figure 3 of Krings 2017