Category Archives: Carcinoma of the salivary glands

Chromosomal changes traveling with ETV6-NTRK3 in secretory carcinoma of the salivary glands

Gregor Krings led a multi-center group from the University of California, San Francisco, to compare histology and genetics of nine secretory carcinomas of the breast with six MASC salivary gland tumors. This post looks at salivary gland secretory carcinoma chromosome changes in the Krings study that were not observed in breast secretory carcinomas.

Diagram showing genomic alterations in various patients with their sex and age.

A summary of genomic alterations traveling with the ETV6-NTRK3 gene fusion.

Secretory carcinoma of the lips, a subset of salivary gland secretory carcinoma

The following images in this post come from case reports of minor salivary gland secretory carcinomas occurring in the lip. The conclusion is that it shares attributes with secretory carcinoma of major salivary glands. The caveat is that the glands of the lip just look different from the major salivary glands.

Picture showing lip labial glands with an inset of tissue histology.

The lip contains labial glands

Molecular comparison of breast and salivary gland secretory carcinomas

Comparing Secretory Carcinoma of the breast with MASC

Gregor Krings led a multi-center group from the University of California, San Francisco, to compare histology and genetics of nine secretory carcinomas of the breast with six MASC salivary gland tumors. For this post secretory carcinoma of the salivary glands will be referred to as MASC, mammary analog of secretory carcinoma of the breast.   Secretory carcinoma of the breast will simply be referred to as SC.

The genetic profile of the tumors in one  image

Diagram showing genomic alterations in various patients with their sex and age.

Figure 1, adapted from Figure 3 of Krings 2017